Appendix 1.26: Valid AJCC 6 Cancer Stages for ICD10CA

To validate the clinical and pathological stage at diagnosis, the ICD-10-CA diagnosis is converted into the appropriate AJCC Site Group using the table in the first spreadsheet in the attached file. Then the stage is validated using the table in the second sheet.

Stage can be reported using Arabic or Roman numerals, and alpha characters can be either upper or lower case. (e.g. 2a, 2A, IIa, and IIA are all equivalent and permissible.) However, for simplicity the second table below only includes Roman numerals with upper case alpha characters.

ICD-10-CA codes not present in the first table are considered non-stageable and are not evaluated in this QA check. Changes in this edition include the removal of all NOS stage values. Other additions are highlighted.

AJCC Validation Table

Below is a .PDF file highlighting the "Improvements and Changes" for the AJCC Sixth Edition Staging Manual as approved by the American Joint Committee on Cancer, Executive Committee. Note that the published AJCC Staging Manuals do not include these changes.

AJCC Sixth Edition Staging Manual Improvements and Changes

Note: Tables below reflect the “Improvements and Changes” for the AJCC Sixth Edition Cancer Staging Manual as approved by the American Joint Committee on Cancer, Executive Committee. Questions, comments, suggestions regarding the AJCC Sixth Edition Cancer Staging Manual or the changes below in the tables can be directed to American Joint Committee on Cancer by sending email to Valerie Vesich @ vvesich@facs.org.

6TH EDITION: CLERICAL CHANGES

Chapter	Type	Site	Section	Change
4	Clerical 6TH	Pharynx	ICD-0 Codes Page 33	Correct: C09.8 Overlapping lesion of tonsil C10.8 Overlapping lesion of oropharynx C11.8 Overlapping lesion of nasopharynx C13.8 Overlapping lesion of hypopharynx Add: C10.3 Posterior wall of oropharynx Delete: C14.0 Pharynx, NOS C14.2 Waldeyer's ring C14.8 Overlapping lesion of lip, oral cavity and pharynx
10	Clerical 6TH	Stomach	ICD Codes Page 99	Change C16.8, Greater curvature of stomach to C16.6 Greater curvature of stomach
18	Clerical 6TH	Pancreas	Histologies Page 162	Delete: Neuroendocrine carcinoma, NOS and Mixed acinar/ductal endocrine (8246/3 and 8154/3)
22	Clerical 6TH	Soft Tissue	Histologies Page 197	Typo. Change from 9743/3 to 9473/3
24	Clerical 6TH	Melanoma of the Skin	Site code List Page 209	Remove C51 and C60 from site code list (not a valid code and subcategories are listed)
30	Clerical 6TH	Ovary	Anatomy Metastatic Sites: Page 275	Delete M1 from sentence: Primary peritoneal adenocarcinoma is always metastatic at diagnosis (M1).
47	Clerical 6TH	Brain and Spinal Cord	Site code Page 387	Add C70.1 Spinal meninges Add C70.9 Meninges, NOS
48	Clerical 6TH	Lymphoid Neoplasms	Staging Examples Page 401	First paragraph last sentence: “Bone marrow is uninvolved on biopsy. Stage II-Bm”

6TH EDITION: CLERICAL (ADDITIONAL TERMS TO BE ADDED TO SITE/CODE HISTOLOGY LISTS)

Chapter	Site	Histology Name	Code
ALL*	ALL* (see statement below)	Neoplasm, malignant	8000/3
6	Nasal & Sinuses	Olfactory neuroblastoma	9522/3
7	Major Salivary Glands	Squamous cell carcinoma, keratinizing, NOS	8071/3
8	Thyroid	Carcinoma, NOS	8010/3
9	Esophagus	Adenocarcinoma, NOS	8140/3
14	Liver	Carcinoma, in situ, NOS	8010/2
15	Gallbladder	Mucin-producing adenocarcinoma	8481/3
16	Extrahepatic Bile Ducts	Infiltrating duct carcinoma	8500/3
17	Ampulla of Vater	Adenocarcinoma in tubulovillous adenoma	8263/3
17	Ampulla of Vater	Infiltrating duct carcinoma	8500/3
18	Pancreas	Intraductal carcinoma, noninfiltrating	8500/2
21	Bone	Sarcoma, NOS	8800/3
22	Soft Tissue Sarcoma	Spindle Cell Sarcoma	8801/3
22	Soft Tissue Sarcoma	Dermatofibrosarcoma, NOS	8832/3
22	Soft Tissue Sarcoma	Liposarcoma, well differentiated	8851/3
22	Soft Tissue Sarcoma	Myxoid Liposarcoma	8852/3
22	Soft Tissue Sarcoma	Pleomorphic Liposarcoma	8854/3
25	Breast	Adenocarcinoma, NOS	8140/3
25	Breast	Intraductal papillary adenoca w/ invasion	8503/3
25	Breast	Infiltrating duct and lobular carcinoma	8522/3
26	Vulva	Carcinoma, in situ	8010/2
26	Vulva	Squamous cell carcinoma, keratinizing, NOS	8071/3
26	Vulva	Squamouc cell carcinoma, micro-invasive	8076/3
28	Cervix Uteri	Carcinoma, NOS	8010/3
28	Cervix Uteri	Squamous cell carcinoma, micro-invasive	8076/3
29	Corpus Uteri	Carcinoma, NOS	8010/3
29	Corpus Uteri	Epithelioma, malignant	8011/3
29	Corpus Uteri	Mullerian mixed tumor	8950/3
30	Ovary	Carcinoma, NOS	8010/3
30	Ovary	Papillary adenocarcinoma, NOS	8260/3
30	Ovary	Serous papillary cystic tumor of borderline	8462/1
31	Fallopian tube	Papillary carcinoma, NOS	8050/3

6TH EDITION: CLERICAL (ADDITIONAL TERMS TO BE ADDED TO SITE/CODE HISTOLOGY LISTS)

Chapter	Site	Histology Name	Code
31	Fallopian tube	Papillary adenocarcinoma, NOS	8260/3
31	Fallopian tube	Carcinosarcoma, NOS	8980/3
33	Penis	Squamous cell carcinoma, keratinizing, NOS	8071/3
33	Penis	Queyrat erythroplasia	8080/2
34	Prostate	Carcinoma, NOS	8010/3
34	Prostate	Acinar cell carcinoma	8550/3
35	Testis	Seminoma, anaplastic	9062/3
36	Kidney	Carcinoma, NOS	8010/3
36	Kidney	Transitional cell carcinoma, NOS	8120/3
39	Urethra	Clear cell adenocarcinoma, NOS	8310/3
42	Melanoma Conjunctiva	Nodular melanoma	8721/3
43	Melanoma Uvea	Spindle cell melanoma, type B	8774/3
45	Lacrimal Gland	Papillary squamous cell carcinoma	8052/3

Except for the AJCC Chapters that are dependent on site-specific histologies; e.g. melanoma, malignant lymphoma, retinoblastoma, etc.

(6/24/2003)

CONTENT CHANGES FOR ERRATA

Chapter	Type	Site	Section	Change
1	Content 6TH	Purpose & Principles Of Staging	Histopathologic type Page 7	Current: If a specific histology is not listed, the case cannot be staged using the AJCC classification in that chapter. Change: The histology lists are to be used as a guide in determining cases to be staged using the AJCC classification.

AJCC Sixth Edition Clarifications and Changes

The table below reflects the changes to be made to the Sixth Edition effecting TNM definitions and/or staging forms. Revisions of these pages will be provided in “pdf” format on Springer-Verlag, AJCC's publishers, web site at www.cancerstaging.net.

Chapter	Site	Change
3	Lip and Oral Cavity Pages 25 and 31	Change T4 (lip) to T4a (lip) in the Definition of TNM and in the Lip and Oral Cavity Staging form.
22	Soft Tissue Pages 195 and 199	Change Stage groupings to reflect substages IA, IB, IIA and IIB: Stage IA T1a N0 NX M0 G1-2 G1 Low T1b N0 NX M0 G1-2 G1 Low Stage IB T2a N0 NX M0 G1-2 G1 Low T2b N0 NX M0 G1-2 G1 Low Stage IIA T1a N0 NX M0 G3-4 G2-3 High T1b N0 NX M0 G3-4 G2-3 High Stage IIB T2a N0 NX M0 G3-4 G2-3 High Stage III T2b N0 NX M0 G3-4 G2-3 High Stage IV Any T N1 M0 Any G Any G High or Low Any T Any N M1 Any G Any G High or Low
44	Retinoblastoma Pages 372 and 375	Remove: cTNM: Regional Lymph Nodes (N) Remove--N2 Distant lymph node involvement Change Clinical: Distant Metastasis (M) Change cM1 from “Metastasis to central nervous system and/or bone, bone marrow or other sites” to “Distant Metastasis”

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